Amphetamine is known to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit a variety of P450 isozymes and various enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes show slight inhibition of CYP2D6 by amphetamine and minimal inhibition of CYP1A2, 2D6, and 3A4 by a number